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KMID : 0603820120180020123
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Journal of Experimental & Biomedical Science
2012 Volume.18 No. 2 p.123 ~ p.130
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Clinical Evaluation of Human Papillomavirus DNA Genotyping Assay to Diagnose Women Cervical Cancer
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Kim Sung-Hyun
Lee Dong-Sup
Kim Ye-un
Kim Gee-Hyuk
Park Sang-Jung
Choi Yeon-Im
Kim Tae-Ue
Park Kwang-Hwa
Lee Hye-Young
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Abstract
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In this study, we evaluated the human papillomavirus (HPV) genotyping test called MolecuTech REBA HPV-ID® (YD Diagnostics, Seoul, Korea) for 704 women who also had cervical cytological evaluations by Thin Prep. The infection rate of high-risk HPV genotypes was 56.6% in patients with normal cytology, 59.8% in those with benign, low-grade squamous intraepithelial lesions, 51.4% in those with atypical squamous cells of uncertain significance, 92.3% in those with high-grade squamous intraepithelial lesions, and 94.1% in those with squamous cell carcinoma or adenocarcinoma. HPV 16 was the most common genotype detected in any lesion, followed by HPV 53, 58, 33, 52, 45, 31, and 35, in order. The HPV DNA test with PCR-REBA is a very highly sensitive, but less specific, method. The infection rates and HPV genotype distribution of non-Korean people versus people from South Korea showed regional differences.
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KEYWORD
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Human papillomavirus (HPV), Women cervical cancer, Clinical evaluation, PCR-REBA
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